ABSTRACT
To determine the seropositivity for viral hepatitis B, hepatitis C and HIV in healthy blood donor population of Northern areas of Pakistan. The blood donors attending the blood bank of Hayatabad Medical Complex, Peshawar were screened for seromarkers of viral hepatitis B, C and HIV by using enzyme linked immunoassay [ELISA] over a period of 05 years. The data of blood donor screening was obtained from Services Hospital, Peshawar for comparison. Blood donors screened at H.M.C. Hospital showed seropositivity of 1.40% and 1.34% for hepatitis B and hepatitis C respectively from 1999 - 2003. Screening of blood donors at Services Hospital, Peshawar during the same period, detected 1.75% HBsAg positive and 2.60% anti-HCV positive subjects. No HIV positive blood donor was detected in both the hospitals during this period. This study concluded a decreasing trend in the seroprevalence of viral hepatitis [B and C] in the blood donor population of Northern Pakistan
Subject(s)
Humans , Male , Female , Hepatitis B , Hepatitis B virus , Hepatitis C , Hepacivirus , HIV , Seroepidemiologic Studies , Cross-Sectional Studies , Mass ScreeningABSTRACT
To evaluate the sensitivity of mean corpuscular volume [MCV], mean corpuscular haemoglobin [MCH] and red blood cell [RBC] count for screening of beta thalassaemia trait [BTT] in population of Northern Pakistan. Blood samples from more than five hundred patients admitted in Hayatabad Medical Complex Hospital, Peshawar were taken and analyzed by Sysmex KX-21 Haematology Analyzer. MCV <80 fl, MCH <25 pg and RBC count >/= 5.0x10[12]/L were used for detecting BTT. HbA2 and serum ferritin levels were used to confirm the diagnosis. Forty-eight [8.5%] out of 563 subjects studied were found to have low MCV and MCH with normal or slightly raised RBC count. HbA2 and serum ferritin levels confirmed 44 patients as BTT, 03 as BTT with iron deficiency [ID] and one case of iron deficiency anaemia [IDA]. The analysis of the results showed 100% sensitivity and a positive predictive value of 97.9% of this screening procedure. The study concluded that low MCV and MCH in association with slight erythrocytosis is a reliable and sensitive index for screening beta thalassaemia trait
Subject(s)
Humans , Male , Female , Erythrocyte Indices , Erythrocyte Count , Mass Screening , beta-Thalassemia/diagnosisABSTRACT
A study was planned to determine the seropositivity for viral hepatitis B, hepatitis C and HIV in healthy blood donor population of Northern areas of Pakistan. The blood donors attending the blood bank of Hayatabad Medical Complex, Peshawar were screened for seromarkers of viral hepatitis B, C and HIV by using enzyme linked immunoassay [ELISA] over a period of 05 years. The data of blood donor screening was obtained from Combined Military Hospital, Peshawar for comparison. The changing trends in the prevalence of these viruses were compared. Blood donors screened at H.M.C. Hospital showed seropositivity of 1.40% and 1.34% for hepatitis B and hepatitis C respectively from 1999 - 2003. Screening of blood donors at CMH, Peshawar during the same period, detected 1.75% HBsAg positive and 2.60% anti-HCV positive subjects. No HIV positive blood donor was detected in both the hospitals during this period. This study concluded a decreasing trend in the seroprevalence of viral hepatitis [B and C] in the blood donor population of Northern Pakistan